{"id":4953,"date":"2025-09-15T01:53:21","date_gmt":"2025-09-14T20:23:21","guid":{"rendered":"https:\/\/regisdigitals.com\/client\/Sunact\/?page_id=4953"},"modified":"2025-10-27T11:42:10","modified_gmt":"2025-10-27T06:12:10","slug":"immunotherapy","status":"publish","type":"page","link":"https:\/\/regisdigitals.com\/client\/Sunact\/immunotherapy\/","title":{"rendered":"Immunotherapy"},"content":{"rendered":"\t\t
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Therapies<\/h6>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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What is Immunotherapy?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Bone Marrow Transplants and Stem Cell Transplants follow nearly identical procedures, the key distinction is simply the source from which stem cells are harvested.<\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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How does Immunotherapy work?<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Checkpoint inhibitors block \u201coff switches\u201d like PD-1\/PD-L1 and CTLA-4 on immune cells, reactivating T-cells to attack cancer cells more effectively. Newer checkpoints like LAG-3 can also be inhibited to reverse T-cell exhaustion and enhance anti-tumor responses.<\/span><\/p>

  1. PD-1 (Programmed Cell Death-1 receptor):<\/strong> Tumors express PD-L1 to bind PD-1 and suppress T-cell activity; inhibiting PD-1 disrupts PD-1\/PD-L1 interaction and reactivates T-cells. (Eg: include Pembrolizumab, Nivolumab, Cemiplimab, and Dostarlimab)<\/span><\/li>
  2. PD-L1 (Programmed Death Ligand-1):<\/strong> Blocking PD-L1 removes the cancer\u2019s \u201cdon\u2019t attack me\u201d signal, enabling immune recognition and attack. (Eg: Atezolizumab, Durvalumab, and Avelumab)<\/span><\/li>
  3. CTLA-4 (Cytotoxic T-Lymphocyte Antigen-4):<\/strong> CTLA-4 is a brake on T-cell activation; inhibition strengthens T-cell responses. (Eg: Ipilimumab)<\/span><\/li>
  4. LAG-3:<\/strong> LAG-3 contributes to T-cell exhaustion; blocking it can restore function and anti-tumor activity. (Eg: Relatlimab)<\/span><\/li><\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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    Benefits<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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    \"\"<\/figure>

    Durable responses: <\/strong>Some patients experience long-lasting control even after treatment stops, due to immune memory.<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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    Precision against cancer cells by leveraging immune recognition rather than broadly toxic effects.<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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    Can work across multiple cancer types and stages depending on biomarkers.<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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    Often fewer systemic side effects than conventional chemotherapy, though immune-related side effects can occur and require prompt care.<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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    Combines well with other treatments such as chemotherapy, targeted agents, or radiation to improve outcomes in selected settings.<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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    Common side effects and safety<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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    • Immune-related effects can involve the skin, gut, liver, lungs, endocrine glands, and other organs. Early reporting of new symptoms is essential for timely treatment, often with steroids or immunosuppressants.<\/span><\/li>
    • Infusion reactions are uncommon but possible; pre-medication and monitoring protocols are in place during clinic visits.<\/span><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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      Treatment journey<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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      • Before starting: Evaluation may include scans, blood tests, and biomarker testing (e.g., PD-L1) to guide therapy choice.<\/span><\/li>
      • During treatment: Regular infusions or injections at defined intervals with periodic imaging and lab monitoring assess response and safety.<\/span><\/li>
      • After treatment: Follow-up tracks long-term control and manages late or delayed immune effects if they occur.<\/span><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

        Therapies What is Immunotherapy? Bone Marrow Transplants and Stem Cell Transplants follow nearly identical procedures, the key distinction is simply the source from which stem cells are harvested. How does Immunotherapy work? Checkpoint inhibitors block \u201coff switches\u201d like PD-1\/PD-L1 and CTLA-4 on immune cells, reactivating T-cells to attack cancer cells more effectively. Newer checkpoints like […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"footnotes":""},"class_list":["post-4953","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/regisdigitals.com\/client\/Sunact\/wp-json\/wp\/v2\/pages\/4953","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/regisdigitals.com\/client\/Sunact\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/regisdigitals.com\/client\/Sunact\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/regisdigitals.com\/client\/Sunact\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/regisdigitals.com\/client\/Sunact\/wp-json\/wp\/v2\/comments?post=4953"}],"version-history":[{"count":0,"href":"https:\/\/regisdigitals.com\/client\/Sunact\/wp-json\/wp\/v2\/pages\/4953\/revisions"}],"wp:attachment":[{"href":"https:\/\/regisdigitals.com\/client\/Sunact\/wp-json\/wp\/v2\/media?parent=4953"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}